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Image Search Results
Journal: Oncogenesis
Article Title: Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
doi: 10.1038/oncsis.2017.65
Figure Lengend Snippet: Increased Nrf2 expression in human gliomas and in glioma progression. ( a ) BioGPS database shows Nrf2 expression in different human tissues. Brain tissue shows, with exception of the pineal gland, intermediate to low expression levels compared to thyroid and epithelial cells. ( b ) CellMiner analysis of Nrf2 expression in the NCI60 tumor cell lines panel. ( c ) Comparison of 81 GBM specimens and 23 normal brain tissue samples (Oncomine) for Nrf2 mRNA expression. GBM tissues show a significant ( P =8.67 × 10 −11 ) higher expression of Nrf2. ( d ), Rembrandt database analysis of survival rates from glioma patients with different Nrf2 expression levels. Red line=upregulation of Nrf2 >2 × (41 samples), yellow=intermediate (302 samples), blue=all glioma (427 samples). Nrf2 upregulation leads to significant ( P =0.007) poorer overall survival rates.
Article Snippet: Analysis of Nrf2 expression in different tissues and cell lines was performed with the
Techniques: Expressing